Sort by Popularity - Most Popular Movies and TV Shows tagged with keyword "serum"
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1. The Maze Runner (2014)
PG-13 | 113 min | Action, Mystery, Sci-Fi
Thomas is deposited in a community of boys after his memory is erased, soon learning they're all trapped in a maze that will require him to join forces with fellow "runners" for a shot at escape.
Director: Wes Ball | Stars: Dylan O'Brien, Kaya Scodelario, Will Poulter, Thomas Brodie-Sangster
Votes: 509,407 | Gross: $102.43M
2. Deadpool (2016)
R | 108 min | Action, Comedy
A wisecracking mercenary gets experimented on and becomes immortal yet hideously scarred, and sets out to track down the man who ruined his looks.
Director: Tim Miller | Stars: Ryan Reynolds, Morena Baccarin, T.J. Miller, Ed Skrein
Votes: 1,125,093 | Gross: $363.07M
3. Divergent (2014)
PG-13 | 139 min | Action, Adventure, Mystery
In a world divided by factions based on virtues, Tris learns she's Divergent and won't fit in. When she discovers a plot to destroy Divergents, Tris and the mysterious Four must find out what makes Divergents dangerous before it's too late.
Director: Neil Burger | Stars: Shailene Woodley, Theo James, Kate Winslet, Jai Courtney
Votes: 488,850 | Gross: $150.95M
4. Maze Runner: The Death Cure (2018)
PG-13 | 143 min | Action, Adventure, Sci-Fi
Young hero Thomas embarks on a mission to find a cure for a deadly disease known as "The Flare".
Director: Wes Ball | Stars: Dylan O'Brien, Ki Hong Lee, Kaya Scodelario, Thomas Brodie-Sangster
Votes: 163,191 | Gross: $58.03M
5. Logan (2017)
R | 137 min | Action, Drama, Sci-Fi
In a future where mutants are nearly extinct, an elderly and weary Logan leads a quiet life. But when Laura, a mutant child pursued by scientists, comes to him for help, he must get her to safety.
Director: James Mangold | Stars: Hugh Jackman, Patrick Stewart, Dafne Keen, Boyd Holbrook
Votes: 831,015 | Gross: $226.28M
6. X: First Class (2011)
PG-13 | 131 min | Action, Sci-Fi
In the 1960s, superpowered humans Charles Xavier and Erik Lensherr work together to find others like them, but Erik's vengeful pursuit of an ambitious mutant who ruined his life causes a schism to divide them.
Director: Matthew Vaughn | Stars: James McAvoy, Michael Fassbender, Jennifer Lawrence, Kevin Bacon
Votes: 723,476 | Gross: $146.41M
7. Blade (1998)
R | 120 min | Action, Horror, Sci-Fi
A half-vampire, half-mortal man becomes a protector of the mortal race, while slaying evil vampires.
Director: Stephen Norrington | Stars: Wesley Snipes, Stephen Dorff, Kris Kristofferson, N'Bushe Wright
Votes: 298,836 | Gross: $70.09M
8. Captain America: The First Avenger (2011)
PG-13 | 124 min | Action, Adventure, Sci-Fi
Steve Rogers, a rejected military soldier, transforms into Captain America after taking a dose of a "Super-Soldier serum". But being Captain America comes at a price as he attempts to take down a warmonger and a terrorist organization.
Director: Joe Johnston | Stars: Chris Evans, Hugo Weaving, Samuel L. Jackson, Hayley Atwell
Votes: 896,582 | Gross: $176.65M
9. The Amazing Spider-Man (2012)
PG-13 | 136 min | Action, Adventure, Sci-Fi
After Peter Parker is bitten by a genetically altered spider, he gains newfound, spider-like powers and ventures out to save the city from the machinations of a mysterious reptilian foe.
Director: Marc Webb | Stars: Andrew Garfield, Emma Stone, Rhys Ifans, Irrfan Khan
Votes: 702,075 | Gross: $262.03M
10. X-Men: The Last Stand (2006)
PG-13 | 104 min | Action, Adventure, Sci-Fi
The human government develops a cure for mutations, and Jean Grey becomes a darker uncontrollable persona called the Phoenix who allies with Magneto, causing escalation into an all-out battle for the X-Men.
Director: Brett Ratner | Stars: Patrick Stewart, Hugh Jackman, Halle Berry, Famke Janssen
Votes: 540,543 | Gross: $234.36M
11. X2 (2003)
PG-13 | 134 min | Action, Sci-Fi, Thriller
When anti-mutant Colonel William Stryker kidnaps Professor X and attacks his school, the X-Men must ally with their archenemy Magneto to stop him.
Director: Bryan Singer | Stars: Patrick Stewart, Hugh Jackman, Halle Berry, Ian McKellen
Votes: 575,933 | Gross: $214.95M
12. The Mummy (2017)
PG-13 | 110 min | Action, Adventure, Fantasy
An ancient Egyptian princess is awakened from her crypt beneath the desert, bringing with her malevolence grown over millennia and terrors that defy human comprehension.
Director: Alex Kurtzman | Stars: Tom Cruise, Sofia Boutella, Annabelle Wallis, Russell Crowe
Votes: 206,142 | Gross: $80.10M
13. I Am Legend (2007)
PG-13 | 101 min | Action, Drama, Horror
Years after a plague kills most of humanity and transforms the rest into monsters, the sole survivor in New York City struggles valiantly to find a cure.
Director: Francis Lawrence | Stars: Will Smith, Alice Braga, Charlie Tahan, Salli Richardson-Whitfield
Votes: 813,907 | Gross: $256.39M
14. The Incredible Hulk (2008)
PG-13 | 112 min | Action, Adventure, Sci-Fi
Bruce Banner, a scientist on the run from the U.S. Government, must find a cure for the monster he turns into whenever he loses his temper.
Director: Louis Leterrier | Stars: Edward Norton, Liv Tyler, Tim Roth, William Hurt
Votes: 523,382 | Gross: $134.52M
15. The Divergent Series: Insurgent (2015)
PG-13 | 119 min | Action, Adventure, Sci-Fi
Beatrice Prior must confront her inner demons and continue her fight against a powerful alliance which threatens to tear her society apart with the help from others on her side.
Director: Robert Schwentke | Stars: Shailene Woodley, Ansel Elgort, Theo James, Kate Winslet
Votes: 255,000 | Gross: $130.18M
16. Megamind (2010)
PG | 95 min | Animation, Action, Adventure
Evil genius Megamind finally defeats his do-gooder nemesis, Metro Man, but is left without a purpose in a superhero-free world.
Director: Tom McGrath | Stars: Will Ferrell, Jonah Hill, Brad Pitt, Tina Fey
Votes: 295,699 | Gross: $148.42M
17. Morbius (2022)
PG-13 | 104 min | Action, Adventure, Horror
Biochemist Michael Morbius tries to cure himself of a rare blood disease, but he inadvertently infects himself with a form of vampirism instead.
Director: Daniel Espinosa | Stars: Jared Leto, Matt Smith, Adria Arjona, Jared Harris
Votes: 153,295 | Gross: $73.87M
18. Allegiant (2016)
PG-13 | 120 min | Action, Adventure, Mystery
After the earth-shattering revelations of Insurgent, Tris must escape with Four beyond the wall that encircles Chicago, to finally discover the shocking truth of the world around them.
Director: Robert Schwentke | Stars: Shailene Woodley, Theo James, Jeff Daniels, Naomi Watts
Votes: 134,126 | Gross: $66.18M
19. Isle of Dogs (2018)
PG-13 | 101 min | Animation, Adventure, Comedy
Set in Japan, Isle of Dogs follows a boy's odyssey in search of his lost dog.
Director: Wes Anderson | Stars: Bryan Cranston, Koyu Rankin, Edward Norton, Bob Balaban
Votes: 190,762 | Gross: $32.02M
20. Overlord (2018)
R | 110 min | Action, Horror, Sci-Fi
A small group of American soldiers find horror behind enemy lines on the eve of D-Day.
Director: Julius Avery | Stars: Jovan Adepo, Wyatt Russell, Mathilde Ollivier, Pilou Asbæk
Votes: 106,535 | Gross: $21.70M
21. The Lair of the White Worm (1988)
R | 93 min | Comedy, Horror
When an archaeologist uncovers a strange skull in a foreign land, the residents of a nearby town begin to disappear, leading to further inexplicable occurrences.
Director: Ken Russell | Stars: Amanda Donohoe, Hugh Grant, Catherine Oxenberg, Peter Capaldi
Votes: 15,085 | Gross: $1.19M
22. Push (2009)
PG-13 | 111 min | Action, Sci-Fi, Thriller
Two young Americans with special abilities must race to find a girl in Hong Kong before a shadowy government organization called Division does.
Director: Paul McGuigan | Stars: Camilla Belle, Dakota Fanning, Chris Evans, Colin Ford
Votes: 115,570 | Gross: $31.81M
23. Penguins of Madagascar (2014)
PG | 92 min | Animation, Action, Adventure
Skipper, Kowalski, Rico and Private join forces with undercover organization The North Wind to stop the villainous Dr. Octavius Brine from destroying the world as we know it.
Directors: Eric Darnell, Simon J. Smith | Stars: Tom McGrath, Chris Miller, Christopher Knights, Conrad Vernon
Votes: 102,107 | Gross: $83.35M
24. Outbreak (1995)
R | 127 min | Action, Drama, Thriller
Army doctors struggle to find a cure for a deadly virus spreading throughout a California town that was brought to America by an African monkey.
Director: Wolfgang Petersen | Stars: Dustin Hoffman, Rene Russo, Morgan Freeman, Kevin Spacey
Votes: 137,730 | Gross: $67.82M
25. Re-Animator (1985)
Unrated | 84 min | Comedy, Horror, Sci-Fi
After an odd new medical student arrives on campus, a dedicated local and his girlfriend become involved in bizarre experiments centering around the re-animation of dead tissue.
Director: Stuart Gordon | Stars: Jeffrey Combs, Bruce Abbott, Barbara Crampton, David Gale
Votes: 71,483 | Gross: $2.02M
26. An American Werewolf in Paris (1997)
R | 98 min | Comedy, Fantasy, Horror
An American man unwittingly gets involved with French werewolves who have developed a serum allowing them to transform at will.
Director: Anthony Waller | Stars: Tom Everett Scott, Julie Delpy, Vince Vieluf, Phil Buckman
Votes: 26,975 | Gross: $26.57M
27. Underworld: Awakening (2012)
R | 88 min | Action, Fantasy, Thriller
When human forces discover the existence of the Vampire and Lycan clans, a war to eradicate both species commences. The vampire warrior Selene leads the battle against humankind.
Directors: Måns Mårlind, Björn Stein | Stars: Kate Beckinsale, Michael Ealy, India Eisley, Stephen Rea
Votes: 161,188 | Gross: $62.32M
28. The Omega Man (1971)
PG | 98 min | Action, Drama, Sci-Fi
Dr Robert Neville has developed an experimental vaccine which makes him the only immune survivor of a biological catastrophe. A gang of homicidal mutants blame science for their condition and attempt to kill him.
Director: Boris Sagal | Stars: Charlton Heston, Anthony Zerbe, Rosalind Cash, Paul Koslo
Votes: 34,061 | Gross: $8.72M
29. The 4400 (2004–2007)
TV-14 | 43 min | Drama, Mystery, Sci-Fi
As the reappearance of 4,400 missing persons on a single day confounds the global community, federal agents on the case slowly discover the ways in which the victims have been changed.
Stars: Jacqueline McKenzie, Joel Gretsch, Patrick John Flueger, Conchita Campbell
Votes: 46,875
30. The Lazarus Effect (2015)
PG-13 | 83 min | Horror, Mystery, Sci-Fi
A group of medical researchers discover a way to bring dead patients back to life.
Director: David Gelb | Stars: Olivia Wilde, Mark Duplass, Evan Peters, Sarah Bolger
Votes: 46,157 | Gross: $25.80M
31. Balto (1995)
G | 78 min | Animation, Adventure, Drama
An outcast Husky risks his life with other sled dogs to prevent a deadly epidemic from ravaging Nome, Alaska.
Director: Simon Wells | Stars: Kevin Bacon, Bob Hoskins, Bridget Fonda, Jim Cummings
Votes: 48,114 | Gross: $11.35M
32. Carriers (2009)
PG-13 | 84 min | Action, Adventure, Drama
As a lethal virus spreads globally, four friends seek a reputed plague-free haven. But while avoiding the infected, the travelers turn on one another.
Directors: David Pastor, Àlex Pastor | Stars: Chris Pine, Piper Perabo, Lou Taylor Pucci, Emily VanCamp
Votes: 49,645 | Gross: $0.09M
33. The Invisible Man (1933)
TV-PG | 71 min | Horror, Sci-Fi
A scientist finds a way of becoming invisible, but in doing so, he becomes murderously insane.
Director: James Whale | Stars: Claude Rains, Gloria Stuart, William Harrigan, Henry Travers
Votes: 39,923
34. Skylines (2020)
R | 113 min | Action, Adventure, Sci-Fi
When a virus threatens to turn the now earth-dwelling friendly alien hybrids against humans, Captain Rose Corley must lead a team of elite mercenaries on a mission to the alien world in order to save what's left of humanity.
Director: Liam O'Donnell | Stars: Lindsey Morgan, Jonathan Howard, Daniel Bernhardt, Rhona Mitra
Votes: 9,206
35. Nutty Professor II: The Klumps (2000)
PG-13 | 106 min | Comedy, Romance, Sci-Fi
Scientist Sherman Klump's inventions, his upcoming marriage to his pretty colleague Denise Gaines, and his reputation, are threatened by his evil clone Buddy Love.
Director: Peter Segal | Stars: Eddie Murphy, Janet Jackson, Larry Miller, John Ales
Votes: 53,272 | Gross: $123.31M
36. Sssssss (1973)
PG | 99 min | Horror, Sci-Fi
A college student becomes lab assistant to a scientist who is working on a serum that can transform humans into snakes.
Director: Bernard L. Kowalski | Stars: Strother Martin, Dirk Benedict, Heather Menzies-Urich, Richard B. Shull
Votes: 3,965
37. Bleeding Steel (2017)
R | 109 min | Action, Sci-Fi, Thriller
A Special Forces Agent is assigned to protect a scientist and his creation from a sinister gang.
Director: Leo Zhang | Stars: Jackie Chan, Show Lo, Na-Na OuYang, Erica Xia-Hou
Votes: 11,068
38. The Coed and the Zombie Stoner (2014)
Unrated | 91 min | Comedy, Horror, Sci-Fi
When a nerdy sorority girl falls in love with a zombie, it's only a matter of time before a zombie apocalypse is unleashed on campus. The sorority girl discovers that weed is the cure--now ... See full summary »
Director: Glenn Miller | Stars: Catherine Annette, Grant O'Connell, Jamie Noel, Aaron Caleb
Votes: 1,578
39. Bride of Re-Animator (1990)
R | 96 min | Comedy, Horror, Sci-Fi
Doctors Herbert West and Dan Cain discover the secret to creating human life and proceed to create a perfect woman from dead tissue.
Director: Brian Yuzna | Stars: Jeffrey Combs, Bruce Abbott, Claude Earl Jones, Fabiana Udenio
Votes: 17,573
40. The Wasp Woman (1959)
Not Rated | 63 min | Horror, Sci-Fi
The head of a major cosmetics company experiments on herself with a youth formula made from royal jelly extracted from wasps, but the formula's side effects have deadly consequences.
Director: Roger Corman | Stars: Susan Cabot, Anthony Eisley, Barboura Morris, William Roerick
Votes: 5,474
41. Tarantula (1955)
Approved | 80 min | Horror, Sci-Fi
A spider escapes from an isolated Arizona desert laboratory experimenting in gigantism and grows to tremendous size as it wreaks havoc on the local inhabitants.
Director: Jack Arnold | Stars: John Agar, Mara Corday, Leo G. Carroll, Nestor Paiva
Votes: 10,771 | Gross: $1.10M
42. Silent Rage (1982)
R | 103 min | Action, Crime, Horror
A sheriff tries to stop the killing spree of a silent maniacal murderer who, as the result of secret genetic experimentation by an unethical scientist, has the ability to self-heal.
Director: Michael Miller | Stars: Chuck Norris, Ron Silver, Steven Keats, Toni Kalem
Votes: 6,699 | Gross: $10.49M
43. The Island of Dr. Moreau (1977)
PG | 99 min | Adventure, Fantasy, Horror
A shipwrecked survivor discovers a remote island owned by a crazed scientist who is carrying out sinister experiments on the island's inhabitants.
Director: Don Taylor | Stars: Burt Lancaster, Michael York, Nigel Davenport, Barbara Carrera
Votes: 7,150 | Gross: $8.72M
44. The Bar (2017)
102 min | Thriller
In bustling downtown Madrid, a loud gunshot and two mysterious deaths trap a motley assortment of common urbanites in a decrepit central bar, while paranoia and suspicion force the terrified regulars to turn on each other.
Director: Álex de la Iglesia | Stars: Blanca Suárez, Mario Casas, Carmen Machi, Secun de la Rosa
Votes: 28,900
45. The Brain That Wouldn't Die (1962)
Approved | 82 min | Horror, Sci-Fi
A doctor experimenting with transplant techniques keeps his girlfriend's head alive when she is decapitated in a car crash, then goes hunting for a new body.
Director: Joseph Green | Stars: Jason Evers, Virginia Leith, Anthony La Penna, Adele Lamont
Votes: 7,572
46. Beyond Re-Animator (2003)
R | 96 min | Comedy, Horror, Sci-Fi
After 13 years in prison, the mad scientist from Re-Animator (1985) gets a new chance to experiment with the arrival of a young prison doctor, who secretly hopes to learn to reanimate dead people. Good intentions turn to horror.
Director: Brian Yuzna | Stars: Jeffrey Combs, Tommy Dean Musset, Jason Barry, Bárbara Elorrieta
Votes: 13,023
47. Night of the Lepus (1972)
PG | 88 min | Horror, Sci-Fi, Thriller
Giant mutant rabbits terrorize the south-west.
Director: William F. Claxton | Stars: Stuart Whitman, Janet Leigh, Rory Calhoun, DeForest Kelley
Votes: 5,452
48. Like Father Like Son (1987)
PG-13 | 100 min | Comedy, Fantasy
A mysterious potion switches the personalities of a buttoned-up doctor and his laid-back son.
Director: Rod Daniel | Stars: Dudley Moore, Kirk Cameron, Margaret Colin, Catherine Hicks
Votes: 6,460 | Gross: $34.38M
49. Monkey Business (1952)
Approved | 97 min | Comedy, Sci-Fi
A chemist finds his personal and professional life turned upside down when one of his chimpanzees finds the fountain of youth.
Director: Howard Hawks | Stars: Cary Grant, Ginger Rogers, Marilyn Monroe, Charles Coburn
Votes: 15,570
50. Robot Monster (1953)
Approved | 66 min | Comedy, Family, Horror
The monstrous Ro-Man attempts to annihilate the last family alive on Earth, but finds himself falling for their beautiful daughter.
Director: Phil Tucker | Stars: George Nader, Gregory Moffett, Claudia Barrett, Selena Royle
Votes: 5,450 | Gross: $1.00M