Episode list

On the topic of History's Biggest American Political Blunders, the six items up for consideration between Craig and the panelists - public relations expert Howard Bragman, and comedians Jen D'Angelo and Jimmy Kimmel - are: Illinois Governor Rod Blagojevich impeached for trying to sell a senate seat; Republican Presidential candidate Herman Cain accused of sexual harassment by employees; New York Governor Eliot Spitzer caught frequenting prostitutes; Idaho Senator Larry Craig charged for lewd conduct for allegedly trying to initiate gay sex in an airport men's room; Delaware Senate candidate Christine O'Donnell admitted to having dabbled in witchcraft; and Vice-President Dick Cheney accidentally shooting his lawyer friend in the face during a hunting trip. The panel generally talks about the guidelines they will use in judging each item, with relativity of the "offense" compared to the situation, to others, and to other things they've done taken into consideration. Hypocrisy of the action and the height of the figurative fall from grace are other factors they consider. They also talk about what isn't on the list but perhaps should have been.

On the topic of History's Worst Medical Advice, the six items up for consideration between Craig and the panelists - Bob Pflugfelder, also known as "Science Bob", and comedians Jordan Carlos and Chris Hardwick - are: smoking is good for you; bloodletting (specifically by leeches) is a cure-all; lobotomies cure mental illness; pulling teeth helps combat depression; the use of mercury can cure a variety of maladies; and drinking one's own urine can purify the body. Beyond the merits of keeping the issue on the list, they talk about which ones are still being done in some form (if even recreationally), the rationale behind the logic of the act, the veracity of each by renowned scientists during their time, and the role religion, metaphysics and faith play in health. Bob does a show and tell of historic unusual medical devices. They also discuss other treatments not on the list and the association of the six to other things people do to their bodies.

On the topic of History's Biggest Frenemies, the six pairings up for consideration between Craig and the panelists - actor/comedians Michael Ian Black, Dan Soder and Courteney Cox - are: basketball stars Magic Johnson and Larry Bird; The Beatles' John Lennon and Paul McCartney; US founding fathers Thomas Jefferson and John Adams; computer technology icons Steve Jobs and Bill Gates; electrical inventors Thomas A. Edison and Nikola Tesla; and late night talk show hosts David Letterman and Jay Leno. The panelists try to decide what the superlative of being the "biggest frenemy" with someone else actually means, and among the list who are truly more friends or enemies as opposed to frenemies. They discuss the relationship Cox had and has with her Friends (1994)' costars, and if frenemies is akin to the concept of sibling rivalry. They also argue the notion of historical standing as a criteria for naming the biggest in the category. Before the audience vote, they close with mentioning pairings that did not make the list but perhaps should have.

On the topic of History's Most Doomed Presidential Campaign, the six campaigns up for consideration between Craig and the panelists - political science professor and former political campaigner Dan Schnur, actor/comedian Bryan Callen and actor Elijah Wood - are: Gary Hart's bid for the Democratic nomination in 1988, which was derailed by his adultery; Michael Dukakis' presidential bid as the Democratic nominee in 1988 which had image problems; Al Gore's presidential bid as the Democratic nominee in 2000 which also had image problems; Howard Dean's bid for the Democratic nomination in 2004 which was largely derailed by a shouting speech he made; John McCain's presidential bid as the Republican nominee in 2008, the loss which is largely blamed on his choice of then unknown Sarah Palin as his running mate; and Mitt Romney's presidential bid as the Republican nominee in 2012 which had problems in tone. The panelists look at the merits of each campaign as the most doomed, and use as unofficial criteria those problems that were the most self-inflicted, and those that perhaps would not be deemed as doomed if they happened today. They also mention campaigns that did not make the list but perhaps should have. Their discussion closes with how these campaigns stack up against what within recent memory seems to be the most unusual current run to the presidency in 2016.

On the topic of History's Worst Tyrant, the six people up for consideration between Craig and the panelists - Professor Laila Lalami, comedian Dan Levy and actor Julie Bowen - are: Adolf Hitler; Pol Pot; Muammar Gaddafi; Genghis Khan; Jong-Il Kim; and Mary I of England also known as Bloody Mary. Before the discussion, Craig explains why Joseph Stalin, arguably the worst, is not on the list, and the inevitability of Hitler being chosen the worst by the end of this discussion. Beyond what each tyrant did and what he/she would have done if given the opportunity such as wipe an entire group off the face of the earth, the panelists look at the geopolitical situation that led to them being able to do what they did, and if they should be given some deductions from being the worst if the world fostered that geopolitical situation. Similarly, they discuss if what led out of their tyranny had some unplanned positivity should also be in their favor as not being the worst. They also discuss whether Mary, the only woman on the list, should be judged differently solely because of her gender, and the extra obstacles women have had in history in becoming leaders. Beyond Stalin, they also mention tyrants that did not make the list but perhaps should have. In the end, Craig reveals if the inevitability he states at the beginning comes to fruition. Their discussion closes with how what these tyrants did compare to what is happening in the world today, and the rise of modern day tyrants and tyrannical ideologies.

Craig is joined by guests Jack Black, comedian Tymberlee Hill and professor Stephen Prothero as they debate and discuss history's craziest cults.

Craig is joined by guests musician Trace Adkins, actress Kate Flannery, and entrepreneur Lori Greiner as they debate and discuss history's greatest invention since 1950.

Craig is joined by guests musician Lars Ulrich, comedian Tom Papa, and journalist Alan Light as they debate and discuss history's most influential band.

Craig is joined by guests actress Maria Bello, comedian Derek Waters, and professor David Eisenbach as they debate and discuss history's most influential drug.

Craig is joined by guests Jay Leno, comedian Mark Forward, and PR guru Howard Bragman as they debate and discuss history's biggest fall from grace.

Craig is joined by guests actor Adam Goldberg, comedian Noel Wells, and Ty Pennington as they debate and discuss history's greatest man-made structure.

Craig is joined by guests Judd Apatow, comedian Kurt Braunohler, and astronaut Mike Massimino as they debate and discuss history's most plausible conspiracy theory.

Craig is joined by guests actress Angela Kinsey, comedian Heather Macdonald, and journalist Joel Stein as they debate and discuss history's biggest presidential bad boy.

Craig is joined by guests actor Tim Meadows, comedian Ian Abramson, and biologist Dan Riskin as they debate and discuss history's dumbest mistake.

Craig is joined by actor Jason Biggs, comedian Josh Wolf, and actor/comedian Michael Ian Black to discuss some of history's greatest unsolved mysteries.

Craig Ferguson is joined by Larry King, comedian Megan Amram, and NASA Astronaut Mike Massimino as they debate and discuss history's greatest unexplained phenomena.

Craig is joined by actor Joel McHale, comedian Thomas Dale, and Astronomer Derrick Pitts as they debate and discuss history's greatest gangsters.

Craig is joined by actress Lisa Kudrow, actress and comedian Yvette Nicole Brown, and political commentator and journalist John Avlon as they debate and discuss history's most defiant moments of the last 75 years.

Craig is joined by actor and comedian Fred Willard, comedian Jo Koy, and journalist Joel Stein as they debate and discuss history's best founding fathers.

Craig is joined by actor Michael Sheen, comedian Russell Peters, and journalist Joel Stein as they debate and discuss history's biggest frauds.

Craig is joined by Regis Philbin, comedian Mark Forward, and former Secret Service Agent Evy Poumpouras as they debate and discuss history's biggest badasses.

On the topic of History's Biggest Douchebag, the six people up for consideration between Craig and the panelists - film historian Leonard Maltin, comedian Echo Kellum and actor Kal Penn - are: Thomas A. Edison; Anthony Weiner; Marge Schott; Bernie Madoff; Donald Trump; and Martin Shkreli. Craig defines the pop cultural term "douchebag" for this context, the term which is meant to imply a bad person, not "Hitler" bad, but someone one would probably not want to be associated with while standing outside the Pearly Gates waiting for judgment. The panelists largely talk about the merits of each of the six as the biggest douchebag by talking about the many and varied exploits of the six which made them all douchebags. They discuss whether the good any of them have done unselfishly for others, like provide meaningful and often well-paid employment, should count in their favor. Because of his current run to become President, Trump is placed in a different standard than the rest. At one point, Craig unilaterally decides to give up control of the decision making, deferring specifically to Echo and Kal for a specific reason. They conclude by talking about the douchebags that did not make the list but perhaps should have.