Actress Jessica Chastain (movie, "The 355"); Ellen welcomes a 7-year-old whose speech has gone viral; "The Voice" season 21 winner Girl Named Tom performs;
Nicole Byer (TV series, "Grand Crew"); guest host Stephen 'tWitch' Boss surprises a former social worker, who opened a low-income school on the south side of Chicago;
Actress Julie Bowen (film, "The Fallout" and podcast, "Quitters"); Anders Holm ("Inventing Anna"); guest host Adam Devine (TV series, "The Righteous Gemstones");
Actor Mahershala Ali (movie "Swan Song"); Martha Stewart (website "Martha.com"); Ellen welcomes freestyle skier Colby Stevenson, who survived a near fatal car crash, made a comeback, won the World Cup, and hopes to go to the 2022 Winter Olympics.
Andrew Garfield (movies "Tick, Tick--Boom" and "The Eyes of Tammy Faye"); Sherri Shepherd (TV series "The Sex Lives of College Girls" and podcast "Two Funny Mamas"); Ellen welcomes two college students who filmed themselves rescuing a dog from an avalanche.
Paris Hilton (TV series, "Paris in Love"); head coach Vontae Johnson of the Trinity Valley Community College cheerleading team and cheerleader Angel Rice (TV series, "Cheer"); Lizzy McAlpine performs;
Kristen Bell ("The Woman in the House Across the Street From the Girl in the Window"); Ellen welcomes back a 12-year-old, who runs his own company and a nonprofit;
Sarah Hyland (vitamin line "Sourse"); UFC champion Juliana Pena; guest host Mario Lopez welcomes a part-time Uber driver who went viral for helping a passenger;
Actress Nicole Ari Parker (TV series, "And Just Like That..."); a couple who run a camp to mentor kids and teach them to treat people with respect, love, and kindness; guest host Stephen tWitch Boss;
Actor Eric Stonestreet (TV series, "Domino Masters"); a 13-year-old reporter; acrobatic group Positive Impact Movement (TV series, "America's Got Talent");
Tyler Perry (movie, "Tyler Perry's A Madea Homecoming"); Glennon Doyle (book, "Get Untamed: The Journal" and podcast "We Can Do Hard Things"); Phillip-Michael Scales performs;
Los Angels Rams player and Super Bowl champion Andrew Whitmore; actress Marlee Matlin (movie, "CODA"); a TikToker tells how she may have saved a customer's life, after dropping off an Instacard order; Sylvan Esso performs;
Actor Greg Kinnear (TV series, "Shining Vale"); guest host Mario Lopez (TV series, "Access Hollywood") welcomes a professional singer who shares vocal lessons on her social media;
Colin Farrell ("The Batman", "After Yang"); Colman Domingo ("Euphoria", "In Five Speeches"); magician Mat Franco ("Magic Reinvented Nightly") in Las Vegas;
Singer Jimmie Allen; Priscilla Block performs; guest hostess Mickey Guyton welcomes a high school teacher who started a non-profit that provides nutrition for low-income students;
Machine Gun Kelly (album "Mainstream Sellout"); Mamoudou Athie (TV series, "Archive 81"); Ellen welcomes a 12-year-old, who went viral on TikTok, for his cover of "End of the Road" by Boyz II Men;