Piper is consumed with insecurities over her impending 10-year high school reunion, but when a she-demon unexpectedly takes possession, Piper becomes very "Coyote Ugly" and it is up to Prue and Phoebe to bring her back.
The sisters trace a mysterious ice-cream van operator who abducts children, but the evil may not be who they initially suspect. Meanwhile, the girls' dad Victor comes for a visit.
The sisters must stop a warlock from executing his plan to steal specific powers from witches in his attempt to kill every whitelighter in the world. Meanwhile, the girls get a new whitelighter named Natalie.
When Prue discovers that one of her ex-boyfriends is being led down the path to becoming a demon, she, Piper and Phoebe risk their lives in an underworld wrestling ring to save his soul.
Phoebe and Piper are lured to the dark side and relish their new evil powers when a shapeshifting warlock tricks Prue into a shot-gun wedding in an effort to steal the Book of Shadows.
Phoebe somehow becomes psychically and physically linked with the violent past of an Old West ghost town complete with horses, petticoats, cowboys and six-shooters and Prue must go back in time to save her sister from a horrifying fate.
Piper is praying for a demon-free wedding day, but Prue's astral self has other plans as dreams take her into a wild world without rules and responsibility that affect reality when the police arrest Prue on suspicion of murder.
Prue is tired of losing her battle to save innocents, and in her effort to fight off the Angel of Death, she has to turn her back on a dying soul when she accepts that she can't fight fate and reconciles with the death of her mother.
Lacking privacy at the Manor, Piper concludes that she and Leo should move to their own apartment. In the middle of all this the charmed ones come up against a warlock that actually gets stronger the more times it is vanquished.
A demon wielding the seven deadly sins uses his powers against The Charmed Ones, and after only a few hours exposed to Pride, Gluttony, Lust and Sloth, Phoebe, Prue, Piper, and Leo may self-destruct.
Cole officially joins the good fight when he goes undercover in an underworld brotherhood to help Prue, Phoebe, Piper, and Leo learn more about the evil. Their trust in him falters when it looks as though they are being double-crossed.
Phoebe is worried when her love, Cole stays undercover in a demon Brotherhood, but the danger turns dire when Cole's old mentor plots to bring out his evil side and turn his massive powers against the Charmed Ones.
While the Charmed Ones are hunting for a demon they inadvertently turn Prue into a Siberian husky with a wayward spell . Meanwhile, Cole seeks an alchemist's help in removing the human side of his soul.
Prue and Piper bring a doctor to the manor, to protect him from a powerful demonic assassin named Shax, who was sent by The Source. When Shax breaks into the manor, he throws Prue and Piper through a wall, causing them to almost die.
The Power of 3 has been destroyed. Prue is dead, but while Piper and Phoebe mourn and Cole is confronted by two demonic bounty hunters a young girl finds herself drawn to the Halliwells.
Phoebe and Paige must work quickly before Piper is tricked into giving up all of their powers when The Source taps into her brain, altering her perception of reality and placing her in a mental institution.
Cole's past comes back to haunt him when a widow tracks him down seeking vengeance for her husband's death. Meanwhile Piper and Leo test their readiness to become parents.
The Charmed Ones must protect the muses from a warlock who is trapping them into a magical ring and using their inspiration to make the Forces of Evil more powerful.