Lex Luthor returns, kidnaps Lana, forces her to marry him, and assumes the identity of a doctor that created a weapon that could paralyze Superboy forever.
Superboy is aided by Professor Peterson and the two believe that he will one day be able to use his legs and powers again. Lex Luthor taunts the superhero with his new bride, Lana.
Bizarro, an imperfect duplicate of Superboy, is accidentally created when the real Superboy steps in front of Professor Peterson's new duplicating ray.
Superboy battles to free Lana from Bizarro while Prof. Peterson uses his duplicating ray on kryptonite to create Bizarro Kryptonite with the hope that it will end the Bizarro menace.
Superboy and Lana pretend to be the adoptive parents of Mr. Mxyzptlk when he returns from the fifth dimension to stop the havoc caused when a giant follows him seeking revenge.
After running tests on kryptonite to try and neutralize its effects on Superboy, the military accidentally alters it so it has emotional effects on him, making him apathetic.
Superboy falls under the spell of the evil sorcerer Prodo until a mysterious man named Brimstone lends his assistance. Philip Michael Thomas guest stars.
After the villain Nick Knack escapes from prison, he captures Lana and Andy and probes their minds discovering Superboys weaknesses. Gilbert Gottfried guest stars.
Johnny Avonasac, a tennis player, finds a mysterious potion left behind by his dead brother that transforms into Johnny Casanova, an overweight slob who also happens to be a magnet for women, including Lana.
A sorceress called Tiger Eye captures Lana and turns her into a snake to lure Superboy into attempting a rescue so she can ensnare him in a spell and make him her own.