MacGyver is kidnapped by enemy agents to retrieve sensitive information he stole from them. To get him to talk, they inject MacGyver with a hallucinogenic drug that will kill him in six hours, unless an antidote they have is administered.
A theft of uranium occurs at a nuclear power plant where an ex-girlfriend of MacGyver's works. She enlists his help to catch the thief which endangers hers and MacGyver's lives.
A cruise ship is the target of a terrorist attack and has three bombs hidden aboard. MacGyver and a friend from the agency are asked to dismantle the bombs before it's too late for the crew and passengers.
Four agents have been betrayed by a mole inside the Agency, leading to their deaths. MacGyver must discover who it is before he becomes the next victim.
In Bulgaria, MacGyver collects a top-secret microfilm and attempts to smuggle it out of the country. At the airport he meets a mysterious beautiful American girl, who turns out to have ties to the Bulgarian Secret Police.
While on a rescue mission in Soviet Afghanistan, MacGyver is shot and wounded. An Afghan woman and her son risk their lives to give refuge to MacGyver. A wounded MacGyver must now outwit the Russian Army to complete his mission.
MacGyver finds himself on a train that gets hijacked by Indian tribesmen. He tries to help them find the Westerners who sold tainted medicine to their tribe and resolve the situation peacefully.
An assassin is primed to knock off a high-ranking official when MacGyver is called in. But in order to foil a master of disguises, Mac must don the best disguise of all...
The military asks MacGyver to check out a new high-tech security system at one of their bases. Complications arise when the computer traps MacGyver inside and attempts to kill him.
MacGyver rescues a friend's young brother in Chinatown who is mixed up with some scam artists presenting him as the Wish Child, a legendary mystical Chinese boy.
Macgyver and four youths are stranded in the wilderness after their plane crashes. Gang rivalries among the youth escalate an already precarious situation.
A nun and some orphans are in need of rescuing by MacGyver from murderous soldiers in Southeast Asia. It turns out that the nun's assistant is an old girlfriend of MacGyver's.
Two rare golden eagles facing extinction are helped by MacGyver. He must simultaneously confront the poacher trying to kill the eagles and eliminate MacGyver.
A teacher of the deaf, who is a friend of MacGyver's, is plagued by nightmares. MacGyver thinks these unexplained nightmares are connected to a plan to hijack a missile-guidance system.
MacGyver becomes stranded and is forced to hitch a ride with a retired couple. Unknowingly, they are in possession of stolen counterfeit money that the mob is trying to recover.