Set after the Meiji Restoration in Otsu, Shiga Prefecture, Japan. Orochi is a giant snake with enormous power. The giant snake revives once every 300 years and brings disaster to the people. This year is the year of Orochi's revival. The Kumo family, who succeeds the Kumo shrine, have 3 sons. The eldest son is Tenka ( Sota Fukushi), the second is Soramaru and the youngest Chutaro. The 3 brothers attempt to block the power of Orochi. Meanwhile, special forces Yamainu try to seal again the power of Orochi to bring peace to Japan, but the ninja group "Anyaku" from the Fuma clan begin their move to gain the power of Orochi to overthrow the government. Surrounding the Orochi's revival a three-way battle takes place between the brothers, special forces Yamainu and ninja group Anyaku from Fuma clan.