In the small town of Tawachi, fisherman Larry Swanson catches a rainbow trout that is inhabited by a liquid life force called the "OOZE" which takes over his fluids and consciousness. It is soon sought after by a conspiracy theorist, a rich copper baron, detectives, Intergalactic crustacean wizards, an end times-believing cult leader, and other strange beings. Thus begins a wacky psychedelic chase to catch the "OOZE" as the walls of reality start to cave in on itself.