The song was included on the compilation albums Nothing Safe: Best of the Box (1999), Greatest Hits (2001), and The Essential Alice in Chains (2006).
A remixed version of the song was included on the box set Music Bank (1999).
"Again" peaked at number eight on the Billboard Mainstream Rock Tracks chart.
The track peaked at number 36 on the Billboard Modern Rock Tracks chart.
The song was nominated for the Grammy Award for Best Hard Rock Performance in 1997.