The voice Maurice LaMarche uses for Brain in Animaniacs (1993), Pinky and the Brain (1995), and Animaniacs (2020) is essentially the same as the one he uses for Orson Welles in The Simpsons, as the voice of Brain is largely based on Lamarche's impersonation of Welles.
The episode centers around Professor Frink. Fox-owned FXX ran a Simpsons marathon centered around Frink on the day this aired for the first time.
Chalkboard gag, written by Homer while Bart watches: "Strangling is not an effective parenting tool"
Billboard gag: "Moe's Tavern: Now with Ladies Room"
Moe likely gets his wish in this episode as he has always complained about his bar not having a ladies room due the bar being mostly men only and no female customers.