"Ain't Your Mama" became Lopez's first chart appearance in some European territories in over four years, such as Spain and Switzerland, as well as her highest in years in countries like Finland and France.
It peaked at 76 in the United States.
After a full tracking week, the song debuted at number 92 on the US Billboard Hot 100, registering 1.8 million streams in the US.
"Ain't Your Mama" reached number 5 in Germany, becoming one of the highest peaking singles of Lopez's career and her first top ten hit since "On the Floor" (2011).
The single has since been certified platinum by the Bundesverband Musikindustrie for exceeding 400,000 units.