Raj gets in a Twitter war with Neil deGrasse Tyson, who calls Raj a "random nobody", and later tells him not to mess with him, since he's the one who kicked Pluto out of the solar system. Tyson apparently doesn't remember Raj, who introduced him to Sheldon in the season 4 episode The Apology Insufficiency (2010). Also, in that episode, Tyson told Sheldon that he actually wasn't the one who demoted Pluto, but that it was due to a vote by the International Astronomical Unit (however, Tyson had already supported the notion for years, and later apologized to Sheldon anyway).
This episode premiered on the 11th anniversary of the pilot episode.
Final appearances of Bill Nye and Neil deGrasse Tyson. Nye was seen once before in The Proton Displacement (2013). Tyson appeared once as himself in The Apology Insufficiency (2010), and the second time post-credits in a photoshopped picture in The Misinterpretation Agitation (2014).
Title reference: Sheldon and Amy need to find a new way to deal with Sheldon's schedules in order to make their marriage work.
First episode of season 12, which was announced as the final season for The Big Bang Theory (2007), mostly because of Jim Parsons' desire to move on to other projects.