Rolling Stone ranked the song at number fifteen on their list of the 100 Best Songs of 2007.
It was also commercially successful, peaking at number one in Ireland and reaching top ten positions in Australia, Austria, Canada, Denmark, Finland, New Zealand, Sweden and the United Kingdom.
The video was nominated in three categories at the 2008 MTV Video Music Awards and won all of them, including Video of the Year.
The self-manifesto song's lyrics are written like a biography retelling Spears' mishaps.
"Piece of Me" is an electro song that runs through a down-tempo dance beat.