Blackwell's Island was later named Welfare Island, and subsequently renamed Roosevelt Island. Due to the number of hospitals and asylums, the area was designated as a Hospital Park. By the mid-twentieth century, it became a mixed-use zone, through the introduction of residential developments, and by the twentieth-first century, a satellite campus of Cornell University and Franklin Roosevelt's Four Freedom Park was established at the Southern end of the Island.
St. Elizabeths Hospital was the site of a Federal Mental Asylum frequented by members of the armed services who were deemed unfit for duty. In the early twenty-first century, it is slated for redevelopment as the Headquarters of the Department of Homeland Security.