The episode title "Who is He (And What is He To You)?" is named after the song by Bill Withers.
First episode of Grey's Anatomy to not feature Ellen Pompeo in any way.
Wallace Langham, who plays "Dr. Corridan" in this episode, famously played "David Hodges" in the show CSI: Crime Scene Investigation and its sequel Series CSI: Vegas. As a nod to his character, a couple in this episode, played by Zoë Hall and Skye Marshall, bear the same last name, playing Risa and Mary Hodges.