This episode includes an epitaph for the late Powers Boothe, who died in his sleep two days earlier, before the ending credits. He played Gideon Malick.
The title sequence for this episode was changed back to the Agents of S.H.I.E.L.D.: Ghost Rider title sequence.
When talking with Ghost Rider, Daisy refers to him going into a "hellmouth." This is a term from Joss Whedon's Buffy the Vampire Slayer (1997). In it, Buffy's town is said to stand on a Hellmouth.
This is the first season finale since season 1 to not be aired alongside the previous.
This is the first season finale to be written by Jeffrey Bell as opposed to Maurissa Tancharoen and Jed Whedon.