When Anton Ivanov tells AIDA that his Life Model Decoy is "designed only for killing", this is an allusion to Marvel villain M.O.D.O.K. (Mental Organism Designed Only for Killing).
Since the characters escaped the Framework, the title sequence of this episode features a normal "Agents of S.H.I.E.L.D." title whereas this title was changed into "Agents of HYDRA" in the previous episodes in the final pod for the fourth season.