This is the first episode to feature Martin Henderson as Dr. Nathan Riggs. This marks the first time since the premiere that an actor is added to the main cast without making a couple of guest appearances first.
While most episodes feature a narration by Meredith or another character, this episode differs by the fact that the narration is actually being said to a group of characters by Meredith, rather than to the audience.
During this episode, Meredith Grey is wearing the favorite ferry boat scrub cap in surgery that belonged to Derek Shepherd.
This episode's title originated from the musical The Me Nobody Knows.
At first, Martin wasn't supposed to appear in this episode, but it was decided to bring him onto the show a few weeks early.