Inspired by true events at Alabama's only women's Prison, Tutwiler follows the story of a woman named Lori, incarcerated in the prison who is raped by a security guard and becomes pregnant. The majority of children that are born inside Tutwiler are sent to an orphanage called The Adullam House if there are no relatives able to take them in. The film picks up with Lori's daughter Shay, who is now in her 20's and seeking to build a relationship with her mother who is still imprisoned at Tutwiler, living in heinous and repulsive circumstances.