In an interview, Paget Brewster said that during her audition she treated John Stamos "like a child" and that's how she got the part of Sara.
In the third episode, Paget Brewster opens a laptop and takes a "Which 'Friends' character are you?" quiz and gets Ross. Brewster was in six episodes of Friends where she got together with both Joey and Chandler.
First major television role of Josh Peck outside of Nickelodeon, and is the first time he's had a major television role since Drake & Josh (2004).
Full House co-star Bob Saget has a cameo in the pilot episode.
First episode was featured on United Airlines flights, before the regular network television premiere of the series, at no charge to the passengers.