Cast (in credits order)
| Yuri Lowenthal | ... | Spider-Man (voice) | |
| Tara Strong | ... | Mary Jane / Black Cat (voice) | |
| John Eric Bentley | ... | Nick Fury / Soldier (voice) | |
| Christopher Daniel Barnes | ... | Electro / Vulture (voice) | |
| Nolan North | ... | Green Goblin / OSCORP Announcer (voice) | |
| Laura Bailey | ... | Spider-Woman (voice) | |
| Travis Willingham | ... | Jack O'Lantern / Morlun / Sandman (voice) | |
| Neil Kaplan | ... | Jennix / Daemos (voice) | |
| Tara Platt | ... | Carlie Cooper (voice) | |
| Kyle Hebert | ... | Solus / Doctor Octopus / J. Jonah Jameson (voice) | |
| Mary Elizabeth McGlynn | ... | Silver Sable (voice) | |
| Matthew Mercer | ... | Hydro-Man / Karn (voice) | |
| Ben Diskin | ... | Spider-Ham (voice) | |
| Fred Tatasciore | ... | Mysterio (voice) | |
| Chiara Zanni | ... | Annie Parker (voice) | |
Produced by
| Barnabe Anglade | ... | executive producer |
| Karim Benfares | ... | executive producer |
| Mike Doonan | ... | producer (as Mike Doonon) |
| Steve Melanson | ... | lead producer |
Music by
| Pascal Dion | ||
Art Department
| Anton Kozlov | ... | 3d artist |
Sound Department
| Arnaud Galand | ... | audio director |
| Gene Rozenberg | ... | sound designer |
| Scott Shaw | ... | sound designer |
| Mathieu Vachon | ... | audio director |
| Dave Walsh | ... | recording manager (as David Walsh) |
Additional Crew
| Courage Copper | ... | game design intern |
| Jason Cushing | ... | voice-over manager |
| Susanne Hunka | ... | voice-over manager |
| James Lafferty | ... | project manager |
| Sierra Leoni | ... | production coordinator |
| Baptise Marmey | ... | creative director |
| Jamie Simone | ... | voice director |
