In the opening credits the sun sets counterclockwise, and then the stars rise clockwise.
When family members are travelling from the Keys to Miami, several times they are shown driving across the MacArthur Causeway towards downtown Miami, from Miami Beach. In order to do this, they would have had to arrive in Miami, drive over to the beach, and then return to the mainland.
The Florida Keys bisect the meeting of the Atlantic Ocean and Gulf of Mexico. The Atlantic is on one side of the islands; the Gulf on the other. The opening shot of the series titles is purportedly of a sunset over the Atlantic Ocean. In Islamorada the sun rises over the Atlantic and sets over the Gulf. The editors have taken a sunrise over the Atlantic and reversed it to make the sun go down. (This is from a former Islamorada resident)