Neve Campbell starred on the show as Lizzie Shepherd, the sister of Dr. Derek Shepherd. Patrick Dempsey who plays Dr. Derek Shepherd played together with Neve Campbell in Scream 3.
Karev keeps referring to Wilson as princess. Wilson (Camilla Luddington) starred as Kate Middleton in the 2011 movie "William & Kate".
Every episode of the show is named after a song. "Love Turns You Upside Down" is a song by Edwin Moses.