While giving a lecture on Garret Jacob Hobbs, Will states that each of Hobbs's victims had the same hair and eye color as his daughter, Abigail. However, when he shows photographs of the victims, they all have dark brown eyes, while Abigail's eyes are blue.
They shoot an elk in the forest and on the car they have a mule deer. Wrong species.
After Abigail kills Nicholas in her house and Dr. Bloom is recovering in the ambulance, she asks where Abigail is Will replies saying that Lecter took her back to the hotel, the next scene Dr. Lecter in his office and he addresses an off-screen Abigail and she asks how he knew it was her, he replies that the hospital called telling him that she climbed over the wall he then states that she had nowhere else to go that home was out if the question.
Doctor Bloom tells Abigail she is not a doctor of medicine but a psychiatrist. Psychiatrists by definition are doctors of medicine.
Alana tells Abigail her mother was cremated per her living will. A living will deals with end of life instructions and would not include post-mortem instructions.
There are boxes sealed with EVIDENCE tape all over the Hobbs crime scene. No way would actual evidence remain unguarded at a crime scene.
Hannibal Lecter called Garret Hobbs from a regular land line but it is somehow untraceable.