When Chucky kills Barb, a close-up of her face shows she has green eyes. When Chucky sends one of the eyeballs down the steps, it is blue.
When the flashback of Sarah's death is shown, Chucky's face has stitches where as the stitches are revealed later on when barb removes his plastic skin half way through the movie, not when he killed Sarah.
When Barb is revealing Chucky's scars the placement of them changes along with his entire facial structure from one cut to the next.
Revealing the scars on Chucky's face shows that Chucky is the same doll from the past two films. This being the case, the doll should be "human." When Nica chops off Chucky's head it is just a regular doll head. This would also mean that Chucky can not take over the body of the first person he revealed himself to, which would have been Sarah (whom he killed) not Alice.
In the BBQ scene, young Barb has brown eyes, but older Barb has green eyes.
It's unlikely that Father Frank would have died from the rat poison in his chili. The reason it works on rats is because they don't have a gag reflex and don't vomit. If a human were fed rat poison, they'd immediately vomit it up.
When Charles first meets Sarah, Daniel and Barbie the scene apparently takes place in summer as the weather is pleasant, everyone is in summer clothing and having a barbecue. Sarah is also heavily pregnant but a few scenes later the the film is set in winter and Sarah is still heavily pregnant. This would be impossible as a woman would not be pregnant at this late stage for more than 6 to 5 months.
Eyeballs do not bounce, as occurs after Barb's death.
During the dinner scene it is implied Alice is the one who is eating the rat poisoned chili but Father Frank seems to be the one who is affected not Alice and Chucky was only seen putting rat poison in one bowl not two. This was an intentional narrative choice to mislead the audience.
When Nica goes to investigate the screams in the first part of the movie as she opens and closes the door she appears to be moving in a way that implies she is standing and not sitting in the wheelchair.
When Nica crawls to the elevator to escape Chuckie, she bends her legs in order to shut the elevator door.
When Nica looks up Chucky on the internet, she gets a search result for murders in Niagara Falls (the events depicted in Child's Play 3 (1991)), however, "Niagara" is misspelled "Niagra".
When Chucky is revving the car engine, the sound is of a large engine, such as a big block V8 when the actual vehicle could not make that sound.
When Nika receives Chucky's package in the first minutes of the film, she talks to the courier guy with a big snot in her right nostril. It can be seen during the entire dialogue.
Rat poison would not have made Father Frank crash his car, adequately administered it would just have resulted in slow internal bleeding. There is no immediate causality between eating rat poison and the fatal crash. However, it is not even exactly clear who ate the poisoned portion.
The car in the garage is a 2000-2003 Ford Taurus with 2 engine options a 3.0L Vulcan E85 V6 & a 3.0L Duratec V6. However, the sound effect used for the car belongs to a V8.
In the flashback scene where it shows the past dinner party with Charles in the background, it shows a close-up of Charles with Ray-Bans on. There is a P (polarized) on the Ray-Bans which have only come out recently, post 2010.
When Chucky is trying to kill Nica by the fumes of the car, you can hear him hit the gas and the engine revving but the smoke from the silencer has a constant flow.
When Alice goes to the bathroom and gets up from the toilet to investigate the reason the curtain is moving, when she stands up she takes a deep breath through her nose but it sounds as if coming from her mouth.
The live-cam hidden inside of Chucky is never shown to be turned off, and is still on at the the point when he kills Ian and attempts to kill Nica. It could have been used as evidence to support Nica's version of events in the trial.
An important plot point is the phone outage and lack of cellular service during the storm. Yet during the outage there is plenty of bandwidth for internet searches and even video calls. Nica could easily have called out using WiFi.
During the dinner scene. Barb asks for the Salt and proceeds to use it as a shaker, instead of a grinder.