- Scooby-Doo: Nova. What do I do? The Heart of the Jaguar is broken.
- Nova: The spear was never the Heart of the Jaguar. The Heart of the Jaguar is something else, Scooby-Doo. At the right moment when the heart is clear, you will know what to do.
- Scooby-Doo: Seriously? Just tell me what to do!
- Nova: You will know. You will see. You will feel.
- Velma Dinkley: With no actuality of wave function collapse, alternative histories and futures are real. I know why everything's different. We destroyed the Entity and by destroying it, it was as if it never existed. So, everything it touched: All the evil, all of the curse, all of the losers in rubber masks and the dumb monster attractions, none of it ever happened. By destroying the Evil Entity, we created an entirely different timeline.
- Daphne Blake: Our neighbors, our families, they've never been negatively influenced by the Evil Entity.
- Shaggy Rogers: It's come undone, all of it. Our actions created a better world where we all have normal and productive lives.
- Daphne Blake: Lives that really aren't ours.
- Fred Jones: Worse than that, gang, we've created a world without mysteries.
- Velma Dinkley: What kind of a world doesn't have mysteries?
- Fred Jones: A world where we don't belong.
- [first lines]
- Nova: A beginning is a very delicate time, much more so an ending. Know then that this is the year 10,191. We, the Annunaki, traveled between layers of the many universes. We came to help you grow, evolve. But not all of us are good. Some are evil, wanting only to feed on your energies. This most evil of all we imprisoned in a crystal sarcophagus between worlds so that he could cause no harm. This evil desires to devour worlds. He manipulated groups of humans to set him free; the Mayan Hunters of Secrets and their jaguar, Spot. The Fraternitos Mysterium and their donkey, Porto. The Alianza Mysterio and their skunk, El Fucho. The Mystery Gang and their bull, Tiny. The Benevolent Lodge of Mystery and their orangutan, Mr. Peaches. The Mystery Fellowship and their cat, Whiskers. Mystery Incorporated and their parrot, Professor Pericles. And the current Mystery Incorporated and their special companion, Scooby-Doo. The time of Nibiru has come. The moment when the planets align, the evil one's strength will be greatest. Free in your world, he will grow more powerful every second. He will destroy your city, your planet, your universe! Only one stands in his way; Scoobert-Scooby-Doo.
- Harlan Ellison: Harlan Ellison here. You can call me Mr. E. I know who you kids are and I know that you created an alternate timeline by destroying that Evil Entity. How do I know this? How you ask in your purblind ignorance? It's obvious as antlers on a chihuahua. I'm a genius! All my years of writing speculative fiction has hyper tuned my psychic mnemonic connection with alternate dimensions. That's why I am able to remember every timeline ever created. And believe me, this has happened before, but you kids have slipped the time stream with me. Very rare. You're very strange. That's why I sent you this message. I've taken up residence as professor of sub-nuclear sciences at Miskatonic University. I want you in my class next semester. I've already got you all admitted, even that weird dog. There's a lot of meddling to do and a lot of mysteries out there that need solving. Don't miss it.
- Scooby-Doo: The heart is us. It's always been us!
- Velma Dinkley: Jinkies! Scooby's right. It can't devour us now and it couldn't touch us earlier, remember?
- Daphne Blake: Not when we stood together.
- Fred Jones: The five of us.
- Velma Dinkley: Our friendship.
- Daphne Blake: Our love for one another.
- Shaggy Rogers: Like, that's the true Heart of the Jaguar!
- Scooby-Doo: And that is something that monster can never take away. Something it can never defeat. It's now or never. Let's do this!