- Age-old analysis on 'can a man and a woman be friends?'
- Chandu (Siddharth) and Siri Chandana alias Siri (Shruthi Haasan) are buddies. They grew up as unselfish friends like one soul with a single body. All of a sudden, Ritu Sharma (Hansika Motwani), a college friend for both joins their company. Things begin change so fast. Chandu deeply loves Ritu Sharma and successfully proposes her. Siri too has her boyfriend in her heart. Her marriage is fixed with one Uday (Navdeep), a US return. The day comes when the guy from the US arrives in Hyderabad to take the hand of Siri. A situation arises that Uday and Ritu believe that Siri and Chandu are in love with each other. Friendship or love, which wins at last? It would form the crux of the story.—Captain
- Chandu and Siri are childhood friends, affectionately calling each other "Faltoos" and "Killer", respectively. Their friendship remains intact as they grow up. Chandu was sent to Mumbai to do an MBA, but learned music instead and returns to the agony of his father. Siri convinces Chandu's father that it is her responsibility to take care of Chandu's career. They go for an audition where they get into a fight with a band and he is sent out. Before that, Siri accepts a love proposal from Uday, who lives in the US, after consulting Chandu. Later, Chandu and Siri accidentally meet their mutual friend in college, Ritu Sharma, and Chandu falls in love with her at first sight. Chandu starts spending time with Ritu to impress her, but Siri feels that she is being avoided. Siri decides to leave for a dancing school in Chennai. Meanwhile, Ritu accepts Chandu's love proposal. When Siri is about to leave, Chandu apologises to her that he had not noticed that she was being avoided. At the same time, Uday comes back from the US to surprise her. Hence, she decides not to leave.
Chandu decides to attend the Airtel music competition in Kochi as a lead guitarist in a band. Siri, Uday and Ritu accompany him there. They stay in a hotel, where Clarity Kanna Rao is the servant. Chandu gets his practice through the band which he fought but they later become friends. Chandu wins the competition with a guitar given by Siri. However, the events in Kochi display a deep friendship between Chandu and Siri attracts the jealousy of both Ritu and Uday. Finally, Uday calls for a break-up by asking to decide between himself and Chandu. Chandu's father defends Uday's opinion and asks Chandu and Siri to realise their love. But, Chandu insists that their friendship cannot be turned into love and tells Uday to marry Siri, promising him that he will not be in touch, see her or talk to her ever. The movie ends with Siri giving birth to Uday's child, while Chandu and Ritu, now a married couple, come to see them at the hospital.
At the hospital, Uday realises his mistake of separating them and asks Chandu and Siri to become friends again. They both reunite. The four friends leave with Siri and Uday's baby in Chandu's car.
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