- Rodrigo Borgia: [to his son] Do you know what is more poisonous than failure in war or politics? Ridicule!
- Vanozza Cattaneo: [Angry that she has been assigned to Lucrezia's wedding] I wish I hadn't been volunteered for this. Far better to arrage a funeral. The dead don't bicker.
- Vanozza Cattaneo: [Angry that she has been assigned to Lucrezia's wedding] Why I am charged with this task remains a mystery.
- Rodrigo Borgia: Well, long may it remain so.
- Rodrigo Borgia: [Rodrigo has been staying up waiting for Juan to come home] I'm a sleepwalker. This wound will not let me rest.
- Rodrigo Borgia: Is it your body or your soul that needs healing?
- Micheletto: [after Cesare releases Benito Sforza over Micheletto's advice] This dog will come back to bite.