Goofs

During the televised press conference towards the end of the movie, the speaker says they are expected to run out of fuel and crash into the Pacific ocean. A flight from LA to Tokyo would surely have enough fuel to make it into inland China/Russia before running out of fuel.

During the opening credits, the audio includes an off-screen flight controller trying to contact TransAtlantic Flight 7500, but in the film Flight 7500's airline is called Vista Pacific.

Although the street address, city and state shown on passenger Lance Morrell's drivers license and baggage tag is the same, the five-digit zip code is different (by one digit).

When the cabin pressure drops, the plastic water bottles are shown collapsing. In reality they would expand.

In the movie the upstairs of the 747 aircraft which is First Class has a movie screen at the front of the cabin. The flight attendants and passengers are shown going downstairs and entering the flight deck. On an actual 747 the flight deck is on the upper floor.

About halfway through the movie: "Nightmare at 20,000 Feet (1963)", an episode of The Twilight Zone (1959) which features a gremlin on the side of the plane, slowly dismantling it while terrifying William Shatner's character is being shown as the in-flight entertainment. In reality, any visuals of that intensity would be censured so as not to cause discomfort in passengers.

During the press conference the speaker mentions that "the oxygen masks malfunctioned." Each mask is completely autonomous and operates as an independent unit connected to it's own oxygen generator. There can't be a failure of the entire system.

Additionally, the flight deck oxygen masks are supplied by a high pressure tank in the cockpit and completely detached from the cabin oxygen system.

Mouth-to-mouth (Rescue Breaths) resuscitation was removed from the CPR protocols in 2008. Brad (Martin), as a paramedic, would have known that. However, anybody with common sense would not perform mouth-to-mouth when the victim's mouth was full of blood. Secondly, the AED only provides the electronic pulse (shock) if it detects Ventricular Fibrillation (VF). If there is no heart rhythm (asystole), or the AED detects any other cardiac rhythm, it will not do anything.

At 25.21 the on-board digital screens in the cabin state that the remaining flight time is 8hrs 20mins, but at 26.34 Chisato Yanagi quotes to the male passenger beside her "We are trapped with a dead body for the next six hours?"