Claire and Annie First Apparnce in Season 2
Caesar discribed Rex's plan as, "[engaging Claire and Annie's] paleomammalian instincts so the fear response would be to cling to the nearest male."
The movie that Rex, Noah, Claire, and Annie see is a parody of Scream.
This is the first time Rex fully cures a non-human EVO, this being a cat.
This episode was written by Tad Stones, creator of Darkwing Duck