Several shots show the corner of Bleecker Street and the Bowery. The street signs have white letters on a green background. In the 1970s, Manhattan street signs had black letters on a yellow background.
Some stickers on the wall of CBGB didn't exist when the club opened.
Songs played in the movie by The Ramones, are Spirit in My House and I Got Knocked Down (But I'll Get Up) recorded by Joey Ramone in 2000 and 2001, 32 years after the movie takes place and 4 years after The Ramones broke up.
In the subway scene where Taxi is waiting for a train, a train which is shown passing by is a modern NYC transit train. NYC subway trains in the 70s did not have digital train information on the sides of the cars.
In some of the scenes of bands playing (notably The Ramones) Marshall amplifiers are shown - the movie is set in the 1970s however a number of the amps and cabinets are JCM800 models, which weren't introduced until the 1980s..
Talking Heads play as a 3 piece (Jerry Harrison having not yet joined), but as "Psychokiller" plays you can clearly hear two lead guitar parts.
When the Police perform "Roxanne" for Hilly, the studio version is used, complete with the infamous sound of Sting accidentally sitting on a piano during the recording at the beginning of the track. They edited out his laugh afterward but did not edit out the piano chord.
In just about every 'live performance' scene there are more audible vocalists than can be seen, and in some cases studio effects are used on the vocals that would have been impossible to recreate live at that time using that venue's equipment (stereo chorus/flanging, etc)
The sidewalk in front of the CBGB in the movie was way too narrow, unlike the real Bowery which has an enormously wide sidewalk.
When Television auditions, Hilly Merv and Ork are outside talking. You can see the building across the street to be abandoned. In actuality there were occupied apartments with a hardware store there.
Hilly specifically requires all performers to play all-original material and no covers, yet Blondie is depicted performing their cover of the 1963 doo-wop hit "Denise" (gender-reversed to "Denis").