This episode is an edited version of the second hour of content from the two-hour primetime Christmas special, MeTV's Super Colossal Cartoon Christmas (2021), which debuted on Monday, December 13, 2021 - eleven days before this episode aired in the normal weekday morning time slot.
Both Mr. Quizzer and Goldie Fisher make rare in-studio appearances beside Bill and Toony. Mr. Quizzer usually joins the show through one of the TV screens in the studio, and globe-trotting Goldie Fisher visits remotely from her world travels. Here both characters appear in the MeTV studio for the "Tic Tac Toony" game (as Goldie says, "Every box of Tic Tac Toony: Home Edition comes complete with a Goldie Fisher").
Characters occupying the squares in Mr. Quizzer's "Tic Tac Toony: Home Edition" game are Goldie Fisher, Bill, Toony, Bill's Mom & Dad, Buddy Buzzer, Imena Bocks, Benny the IT Feller, Sue P., and Mel Attonin.
Featured recurring characters (besides semi-regulars Mr. Quizzer and Goldie Fisher) include tuna-cooking Trisha Brine ("Down-Home Celebrity Chef"), MeTV horror host Svengoolie ("Master of Terrormonies"), prehistoric rubber chicken Kerwyn ("Macabre Mascot"), MeTV cops Det. Abouttoretire and Det. Newtotheforce, Bill's Mom & Dad, washed-up TV host Buddy Buzzer, street mime Imena Bocks, backwoods comedian Benny the IT Feller, marketing consultant Sue P., and peaceful celebrity painter Mel Attonin. Additionally, this episode features the first appearances of marshmallow-tossing Christmas Carol ("Year-Round Yule Celebrator") and eggnog helmet-wearing Santa.
Unlike usual episodes of "Toon In with Me", this episode (taken from the second half of the primetime special, MeTV's Super Colossal Cartoon Christmas (2021)) only features four cartoons, instead of five.