This is the 99th episode of the show.
This is the first time we see Castiel drunk and we can see how he feels from the previous episode.
This is the second time that Sam and Dean have visited Blue Earth, Minnesota, the first occurring in episode 21 of season 1; Salvation (2006).
The preacher's family name is Gideon. Gideons International is a large distributor of Bibles.
The real Blue Earth, Minnesota has a 55 foot tall fiberglass statue of the Jolly Green Giant, who marks the mid point of I-90, America's longest highway.