In 1979, Dupin investigates grave exhumations linked to a drug trial. The younger Roderick, living with Madeline, his first wife Annabel Lee, and young children Frederick and Tamerlane, fails a pitch of Ligadone to Fortunato's CEO, Rufus Griswold, who succeeded Longfellow. In the present, Perry, Frederick, and Pym must deal with environmental concerns involving their properties. When Frederick insults Perry, Perry decides to host a masquerade-themed party at one of the condemned properties to prove his worth, using water from the facility's tanks to signal an orgy. Roderick, suffering from CADASIL, pins hope on Victorine's experimental heart mesh, while Madeline seeks to create AI using Lenore's memories. Perry invites Frederick's frustrated wife, Morella, to his party, planning to seduce her as revenge for his brother's disrespect to him. Verna arrives at the party in disguise and tries to convince Perry to stop the party, to no avail. The sprinklers' spray turns out to be acid and chemical waste, the consequence being death for all but one guest, including Perry. Verna gives Perry a kiss as he dies.