Plot

Columbus, Tallahassee, Wichita, and Little Rock move to the American heartland as they face off against evolved zombies, fellow survivors, and the growing pains of the snarky makeshift family.

One long decade after the post-apocalyptic events in Zombieland (2009), the resilient quartet of survivors--the tough-as-nails zombie exterminator, Tallahassee; his rule-making comrade, Columbus; the free-spirited huntress, Wichita, and her younger sister, Little Rock--find themselves in the bosom of a now-derelict White House. However, in a rabid world still overrun by multitudes of walking dead and mutated strains of evolved animated corpses, a premeditated separation will send the team back to square one, searching, once more, for the promised land. Now, all hope rests on Babylon: an entirely organic commune of blissful vegetarian pacifists who love to party. Is this the end of the road?—Nick Riganas

A decade after their first adventure, the zombie-bashing team of Columbus, Tallahassee, Wichita, and Little Rock move to the American heartland. Here, they face off against evolved zombies, fellow survivors, and the growing pains of their own makeshift family.—Carmen

Ten years after the events of the first Zombieland movie, our heroes - Tallahassee, Wichita, Columbus and Little Rock - are enjoying life in the White House. Then, all of a sudden, Wichita and Little Rock leave. Wichita eventually returns but Little Rock is charting her own course. Tallahassee, Wichita and Columbus set out to find her, accompanied by Columbus's new girlfriend, of sorts, Madison.—grantss

Ten years after the events of the first film, survivors Tallahassee (Woody Harrelson), Columbus (Jesse Eisenberg), Wichita (Emma Stone), and Little Rock (Abigail Breslin) have become experts in identifying and disposing of various Zombie types like Homer (Dumb Zombie), Hawking (Smart Zombie), Ninja (Silent and Deadly Zombie). They move into the abandoned White House after killing a horde of Zombies around it.

Columbus decides to propose to Wichita using the Hope Diamond, while Tallahassee rebuffs Little Rock's hopes of starting her own family with a boyfriend. Little Rock had a strong desire to leave the nest, and Tallahassee wasn't the most understanding father figure. Tallahassee is adamant that this group is her family, and she doesn't need anything else in life. For Christman Tallahassee gifts Little Rock a Colt .45 pistol that belonged to Elvis. Little Rock is not happy to receive another gun as present.

The next morning, Tallahassee finds a note from Wichita and Little Rock, who have left due to Little Rock feeling Tallahassee still treats her like a child and Wichita's fear she is too attached to Columbus. They took off in a weapon converted version of The Beast (the presidential limousine).

Columbus is moping and argues with Tallahassee about ZKOTY (Zombie Kill Of The Year). That went to a farmer in Iowa who mowed down a Zombie with his harvesting tractor. A month later, while exploring a mall, Columbus is startled by Madison inside a candle shop (as Columbus feels that Zombieland smells terrible), who has survived Zombieland alone since she was fourteen inside the freezer of a Pinkberry. Madison (Zoey Deutch) quickly annoys Tallahassee (when she believes that Tallahassee is Columbus' father), but Columbus invites her back to the White House (when Madison starts to flirt with Columbus and pretends to be interested in his rules), where she has sex with him.

Tallahassee hears a noise in the garage, and he and Columbus investigate to find Wichita has returned for more weapons and ammo. Discovering Columbus has slept with Madison, Wichita explains that Little Rock has left for Graceland with a pacifist musician Berkeley (Avan Jogia) and informs the group of more agile and durable "super Zombies". Fearing for Little Rock's safety, the group heads toward Graceland in a rundown minivan without any weapons. Tallahassee is enraged that Little rock is dating musician. Wichita tells Tallahassee that he is over-bearing and is probably pushing Little-Rock away.

On the road, the group tries to commandeer a luxury RV since Columbus has a strict "no clown" policy that prevents them from getting in an ice-cream truck. As they enter the RV the alarm goes off, and zombies attack. Methodically fighting back as a team, leading to Madison being scratched on the foot by a Ninja and being saved by Columbus. They encounter one of the super-zombies that takes multiple gunshots to kill, leading Columbus to nickname it the "T-800" after the Terminator franchise. T-800 is a strain which can only be killed by completely destroying the head.

Madison shows signs of "Zombification" after she is bit in the attack, forcing Columbus to lead her into the forest to shoot her. The trio arrive at a ruined Graceland, with no sign of Little Rock, Berkeley, or The Beast. The group finds "the Beast", Tallahassee's modified presidential limousine stolen by Little Rock, at an Elvis-themed motel run by Nevada (Rosario Dawson), who reveals Little Rock took another vehicle toward Babylon, a hippie commune where no guns are allowed. Bonding over their love of Elvis, Nevada and Tallahassee spend the night together.

The group awakens to find the Beast being crushed by a monster truck driven by Albuquerque (Luke Wilson) and Flagstaff (Thomas Middleditch), who strongly resemble Tallahassee and Columbus. They both share history with Nevada. Super zombies arrive, and Albuquerque explains they have turned back from their journey west due to hordes of super zombies moving east. Facing the super zombies alone, Albuquerque and Flagstaff are bitten, turn into zombies, and are both killed. Nevada talk about "Murrayed" which a term used for shooting somebody because you think they are a Zombie. Apparently, that's how Bill Murray died.

Heading out, the group finds Madison, alive and driving the clown themed ice-cream truck (her Zombification earlier was simply a nut allergy triggered by eating trail mix). Rejoining the group, she explains that her nut allergy caused symptoms similar to Zombification when Columbus spared her in the forest. The group arrives at Babylon, gives up their weapons, and find Little Rock.

Arriving in Babylon, the group give up their weapons and find Little Rock and Berkeley. A satisfied Tallahassee departs (he is happy to see Little Rock safe and sound), only to find a horde of super zombies attracted by the commune's fireworks and runs back to warn the group. Left without guns, Tallahassee devises a plan to kill the zombies with exploding bio-diesel and then have commune members armed with barricade shields corral the stragglers off of a skyscraper with Tallahassee himself as the bait.

The zombie horde is more massive than expected, and the group is surrounded and almost overwhelmed. Luckily, Nevada arrives in Albuquerque's monster truck, rescuing the group, although the vehicle soon rolls over. Escaping upstairs, the survivors corral the zombies off the roof. Tallahassee uses a construction crane hook to dangle just out of reach, but the last two zombies seize his leg as they fall, and Little Rock shoots them with a pistol given to her earlier by Tallahassee, rescuing him. The two reconcile, and Wichita accepts Columbus' proposal of marriage. Little Rock breaks up with Berkeley, who hooks up with Madison; they stay behind as the group, joined by Nevada, leave Babylon. Columbus remarks that they have finally found their home in each other.

During the mid-credits scene, the narration cuts back to 2009. At the start of the outbreak, Bill Murray witnesses Al Roker turn into a zombie during a promotional interview for a third Garfield film. He kills several zombies, including Grace Randolph and Lili Estefan, and escapes. In the post-credits scene, an outtake is shown of Murray making Estefan break character by trying to cough up a hairball.