The colored circle in the center of the screen shown in one scene when Peter, Lois, and Jerome are in the kitchen, just before a commercial break is one of the "wait" cursors from Apple's Mac OS X.
Although hinted at in previous episodes it is confirmed in this one that Quagmire was once in a serious relationship with Cheryl Tiegs and when that dissolved, the emptiness he felt led him to become the sex-crazed man he is now.
Stewie says that he thought Chris Farley died in Tommy Boy (1995) because he fell down a hill. Farley's character never fell down a hill in Tommy Boy. In reality, Stewie meant to attribute Farley falling down the hill to Black Sheep (1996).
Peter's rant about shooting people in the DC area is a reference to the Beltway sniper attacks where in October 2002 John Allen Muhammad and Lee Boyd Malvo shot and killed 17 people in DC, Maryland and Virginia.