Plot

Larry deliberately tries to annoy Loretta, against the advice of a renowned doctor. Later, Larry dooms Richard Lewis' new relationship, and ends up profiting from Leon's indiscretion with the wife of a depressed pal.

Susie gives Larry a GPS as a present. But Larry cuts himself opening it, as the GPS is packed in a vacuum packaging that is tough to open. Larry is miserable with Loretta, who wants Larry to drive her everywhere and wait on her at all times.

Larry takes Loretta to see a doctor who urges patients to "walk out on cancer" by getting rid of toxic spouses, hoping she may be counseled to dump him. Larry sees this doctor on TV talking about how cancer patients can sure themselves by dumping their "toxic" relationships. Larry gets an appointment at the doctor and then acts "himself" at the doctor's office, angering almost everyone off. He also runs into an old acquaintance, gets embarrassed when he doesn't remember his name, overcompensates by trying to hug him and ends up breaking his glasses during the hug. The acquaintance says that he will send a bill for the glasses, which angers Larry. But Larry has to back off when he learns that the guy has cancer.

Larry's attempt to do a favor for Leon backfires, when he inadvertently tips Leon's friend off to the fact that Leon might be sleeping with his wife. Larry had called Leon's friend as he is a huge Seinfeld fan, and it was his birthday. But Larry ends up saying that Leon finds his wife attractive. Leon confronts Larry & is upset as he is having sex his friend's wife.

Larry goes to buy a box cutter so he can open the GPS package.

Several misunderstandings around fellatio lead to Larry offending Richard Lewis's new girlfriend Beverly (Lolita Davidovich). Jeff tells Larry that Beverly gave Lewis a BJ on the way over and now Larry won't talk anything that has been near her mouth. Larry lies to Lewis saying he has a cold and hence didn't kiss Beverly goodbye. Lewis brings Beverly over to Larry & insists that Larry apologize to her by telling her the truth. So, Larry tells her the BJ thingy, which angers her.

Then Larry is driving Loretta over to a lecture by the doctor and on the way over they run into her husband's car, where it seems like the doctor is giving her husband a BJ while he is driving. Loretta is disgusted and forces Larry to turn the car back. The next day, Larry visits the doctor to settle the bills & is confronted by the doctor who thinks Larry didn't let Loretta attend the lecture. Larry tells her the truth that Loretta saw her giving her husband a BJ in the car. The doctor claims that she was looking for the cellphone.

Larry comes home to find that Leon is having sex with his friend's wife and the friend is at the front door. Leon hides the wife in Larry's car. Loretta drives up behind & to her it seems that Larry is being "serviced" by Leon's friend's wife. Loretta leaves Larry and takes the rest of the Blacks (except for Leon) with her. Driving to his next party, Larry finds Jeff's car in an accident. He finds that Susie was giving Jeff a BJ. But now both are stuck. Larry has a box knife, but can't get it open as it is also in vacuum packaging.