While discussing issues in their relationship, Jane says to her mother "Thank God, I thought I was going to have to take a road trip to the desert". The character of Jane's mother is very reminiscent of a character in the film "Boys on the Side" right down to having the same first name, a mother who repairs her relationship with her daughter after the daughter takes a road trip to the desert.
When Fred is hugging Jane goodbye his pinky is painted blue as good luck like Debbie/Jane does.