Brianna May who plays Ruth, was originally cast as the D.A.. This, along with her political aspirations is the reason why her name was kept for the D.A. role, now played by Tabatha Spivey.
Funding for Noxious 2: Cold Case, was stripped away from Writer / Director Kevin Parkinson due to Covid; So Kevin Parkinson financed the movie himself through his production company Vinark Motion Pictures and a successful crowd-fundraiser.
Noxious 2: Cold Case was produced and filmed entirely in Phoenix, Arizona; Except for the scene at Randy's Donuts and LAX airport.