The number 17 is referenced a few times. Klaus bought the tickets to the concert for $17.50 each, Roger was abandoned by the Logans 17 years ago, & Klaus slept for 17 hours.
Pizza Overlord is a reference to Pizza Planet from the film series Toy Story. The Overlord also bears a striking resemblance to Emperor Zurg.
Roger references "a family of actors" and names the Barrymores, the Baldwins, the Olsens, the Fondas, the Estevez/Sheens, the Gabors, the Redgraves, the Beatty-MacLaines, the Arquettes, the Quaids, the Batemans, the Culkins, the Cusacks, the Afflecks, the Wayans, the Douglases, the Bridges, the Dillons, and the Zimbalists as examples.
Introduction of Reginald, the homeless man-turned-koala CIA agent who's "cute as a button".