The Lame Cow Saloon is terrorized by Bud, who is a three-gun man, and Kewpie, who is an expert knife thrower. The proprietor in desperation sends for Nifty Nell, a vampire (Dot Farley). Both fall in love with her, and finally fight it out with their respective weapons at a distance. After all of Bud's cartridges are used up and Kewpie has thrown his last knife they continue in hand-to-hand combat, and as both are about ready to quit from exhaustion a boy appears and tells Nifty Nell that her eight children are hungry and want her to come home. They forget their differences, and take their places in two coffins which an enterprising undertaker has provided.
—Moving Picture World synopsis