In this episode, Brian finds it hysterical when he finds out that Stewie is not in the car. He states that he would love to see his reaction and does an impersonation of him to which he says that he does not do a good Stewie impression. 'Seth McFarlane' does the voice for both characters.
Stewie refers to Quagmire as Bob Hope, a reference to the fact that the character was originally modeled after Hope's features.
Cleveland Brown announced he's getting a spinoff
(The Cleveland Show (2009)) at the very end of the episode.
One of the Fat Albert kids also voiced by Mike Henry
is the basis of baby Rallo of that show.
The music playing towards the end as Stewie watches the rest of the Griffin family return home is the theme song to the Home Alone movies.