At the start of the 'intervention' Penny and Howard move down the couch twice.
When Sheldon gets up from the driving simulator, he does not "unfasten" his seatbelt/shoulder harness which he had put on earlier.
When Penny starts to drink from a cup while she is driving, Sheldon says "Studies have shown that performing tasks such as eating, talking on a cell phone or drinking coffee while driving reduces one's reaction time by the same factor as an ounce of alcohol".
However, these activities would increase one's reaction time, not decrease it. With Sheldon's IQ, he would realise that his statement is incorrect.
As initially noted in this episode, and continually referenced throughout the series, Penny's car is displaying a check engine light. The car is seen to be a Mk1 (first generation) Volkswagen Rabbit Cabriolet, sold in the US in the early 1980's. This vehicle does not have an on-board diagnostic system, thus is not equipped with a check engine light.
In the reverse camera view of the apartment (when the group gathers for Sheldon's intervention) Sheldon and Leonard's desks are placed flush against the wall. In the normal angle, their desks appear to be in the middle of the room.
When asked what color car Sheldon wants, he responds that he wants one that's the pale blue of Luke Skywalker's light saber. This is actually a mistake, as Luke's light saber is green. The pale blue light saber was actually Anakin's, Luke's father. But technically he is correct it was Luke's (even though it was his father's first) since Old Ben (Obi-Wan) gave it to him he did use that one until he made himself a new one that was green.
It makes no sense for Sheldon to lash himself to a bus seat because there are no safety belts. A bungee cord will not improve safety one bit since even in a low speed impact, the body's momentum is far too great to be restrained even by multiple bungee cords, which even far lesser physicists would know.