The actor, David Esposito, who performs the role of Detective Nick Marino, is actually half Colombian and speaks Spanish fluently.
Pilar Larrota who plays the role of the female news anchor, is Colombian.
Nada Clue was filmed in the house of David Esposito's parents. The same house that was used for the short film "Mulk" that also stars David Esposito and Ryan Crepack. The areas of the house that were used for Mulk, were intentionally avoided for this film.
Pilar Larrota was planning to read her lines from a cue card but she couldn't see the words without her glasses. However, the glasses caused a glare so she had to say the lines from memory.
Ryan Crepack decided the night before shooting to shave his beard and just leave his mustache for the character.