Ates Hekimoglu, who is the most distinctive physician in Istanbul Valide Atik Training and Research Hospital, is way different from the definition of a physician with his personality and the way he treats patients. He is well-known for his success in the fields of infectious diseases and neurology. Hekimoglu involuntarily accepts the case of Mine who had a seizure and collapsed while teaching. He approaches this case as a puzzle that waits to be solved. The young teacher's situation deteriorates day by day. Hekimoglu takes on the teacher's case and tries to diagnose the unknown disease with his team which consists of three successful doctors. Hekimoglu leads them like a CSI team. While Hekimoglu takes all the clues in and out of the hospital into consideration, his sharp tongue and unusual methods put him against Ipek who is the administrator of the hospital and his schoolmate.