Anti-Cosmo says, "Hello, Clarice!" when stepping out of the shadows in his cell, referencing the famously misquoted scene in Silence of the Lambs.
Vanilla Ice and Teen Turtle are just 2 of the many references in the Unwish Island episode,
Although this episode premiered in 2005, it was produced in 2004 according to the credits.
This is the first episode Butch Hartman voices Dr. Rip Studwell because Jay Ward did not want to reprise his role as Dr. Rip Studwell