Model Georgina Wilson, Richard Gutierrez's girlfriend, was rumored to be considered to play the love interest of Lupin. But it didn't happen due to a conflict of schedule, since Georgina was still studying in Australia when the shooting started. The role went to 2007 Bb. Pilipinas runner-up Abby Cruz.
Cesar Montano was supposed to be in the series. He, however, backed-out when he was offered to run as Senator by Pres. Gloria Macapagal-Arroyo in the Philippines. He was replaced by Michael De Mesa.
Vic Sotto and Joey De Leon were originally offered the role of Inspector Clavio, but turned it down. The role went to Janno Gibbs.
Ryza Cenon left the project to be the leading woman of Mark Herras in Fantastic Man. LJ Reyes took over the role.
Though there are many differences between this TV series to the anime and the original novel, the series' stories has been adapted from the anime, the novels and the movies.