Dr. Karev previously refers to Jane Doe's eyes as a deep brown in episode #3.16. When Jane is deciding on her new face in this episode, her eyes are clearly green.
When Izzy confesses to Addison that she had sex with George, she does not mention George's name or even say that the person she had sex with was married. She simply says she had sex "with the wrong person." But Addison's immediate response is to ask, "What am I, the go-to person for adultery?" and the conversation then continues about being in an adulterous relationship.