- [repeated line when someone accuses Sheldon of being crazy]
- Sheldon: I'm not crazy. My mother had me tested!
- Sheldon: You're not done with her, are you?
- Leonard Hofstadter: Our babies are gonna be smart and beautiful.
- Sheldon: Not to mention imaginary.
- Penny: So, what do you say Sheldon, are we your X-Men?
- Sheldon: No. The X-Men were named after the X in Charles Xavier. Since I am Sheldon Cooper, you will be my C-Men.
- Howard Wolowitz: [as Sheldon walks away] Oh, that's not a good name.
- Raj Koothrappali: [to a random person] I'm gonna be in People magazine!
- Charlie Sheen: [turns around to him] Call me when you're on the cover.
- Leonard Hofstadter: [after a motorcycle accident, which no one asks him about] My leg is killing me, thanks for asking.