After numerous complaints, the opening credits were changed so that the actors' pictures matched up with when their names appeared on the screen.
First episode featuring the "Royal Diner" set, although the camera setup is different from later episodes. The same diner interior set, with different dressing, had previously been used as a diner in New Orleans in The Man in the Morgue (2006).
Dr. Goodman's absence from the show is explained as him taking a two month sabbatical.
First episode with Tamara Taylor as Dr Camille Saroyan. However, she is only billed as a guest star; she doesn't get promoted to series regular until The Girl with the Curl (2006).
Dr. Brennan says that Dr. Goodman took a 2 month sabbatical to avoid talking to her after hiring Cam. Goodman is never again seen on the show and no explanation is ever given for the extended absence.